TITLE:
The Effect of Si-Doping on the Release of Antibiotic from Hydroxyapatite Coatings
AUTHORS:
Mirjam Lilja, Carl Lindahl, Wei Xia, Håkan Engqvist, Maria Strømme
KEYWORDS:
Titanium Dioxide; Hydroxyapatite; Cephalothin; Drug Release; Si-Doping
JOURNAL NAME:
Journal of Biomaterials and Nanobiotechnology,
Vol.4 No.3,
June
26,
2013
ABSTRACT: Herein, we show that incorporation of ions during
biomimetic coating deposition may be utilized to tailor the drug loading
capacity of hydroxyapatite (HA) coatings. Pure
biomimetic HA (HA-B) and Si-doped equivalents (SiHA-B) where deposited by a
biomimetic process onto titanium dioxide covered titanium substrates. The
antibiotic Cephalothin was incorporated into the coatings by adsorptive loading
and the release was studied in-vitro.
SiHA-B coatings exhibited superior drug
incorporation capacity compared to pure HA-B coatings, resulting in a drug
release profile dominated by an initial 10 min burst effect while a more
prolonged 10 hour release was observed from HA-B coatings. The results
emphasize the possibility to impact the drug release kinetics from implant
coatings by selective doping elements and the use of thin, biomimetic
HA-coatings as drug delivery vehicles. Functionalizing metal implants with
SiHA-B coatings presents an interesting strategy towards creating synergetic
effects through ion- and antibiotic release and, hence, contributing both towards preventing post-surgical
infections while at the same time enhancing the bone-bonding ability.