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B. F. Brehm-Steche and E. A. Johnson, “Sensitization of Staphylococcus aureus and Escherichia coli to Antibiotics by the Sesquiterpenoids Nerolidol, Farnesol, Bisabolol, and Apritone,” Antimicrobial Agents and Chemotherapy, Vol. 47, No. 10, 2003, pp. 3357-3360. doi:10.1128/AAC.47.10.3357-3360.2003

has been cited by the following article:

• TITLE: Biological Activity of Spartium junceum L. (Fabaceae) Aromatic Water

  AUTHORS: Teresa Cerchiara, Giuseppe Blaiotta, Vittoria S. Straface, Emilia Belsito, Angelo Liguori, Barbara Luppi, Federica Bigucci, Giuseppe Chidichimo

  KEYWORDS: Spartium junceum L.; Aromatic Water; Antibacterial Activity; Antioxidant Activity; Cytotoxicity

  JOURNAL NAME: Natural Resources, Vol.4 No.3, June 25, 2013

  ABSTRACT: In this study, antimicrobial, antioxidant and cytotoxic activities of Spartium junceum L. aromatic water (SJAW), obtained by vacuum process distillation, were investigated. Antimicrobial activity of SJAW was evaluated against fungal organisms, Gram-positive and Gram-negative bacteria using agar-well diffusion method. Moreover, the ability of SJAW to sensitize Staphyloccus aureus to antibiotics was also evaluated. The antioxidant activity was examined by 2,2’-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay and the cytotoxic activity of SJAW main components was tested on melanoma RPMI 7932 and normal keratinocytes NCTC 2544 cell lines using the trypan blue method. The preparation did not show antibacterial activity against tested microorganisms and was unable, at tested concentrations/conditions, to sensitize Staphylococcus aureus to antibiotics clindamycin (2 μg) and tetracycline (30 μg). On the contrary SJAW possesses an appreciable antioxidant and cytotoxic activity suggesting its potential use for pharmaceutical applications.