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B. A. Dennison and D. M. Levine, “Randomized, Double-Blind, Placebo-Controlled, Two-Period Crossover Clinical Trial of Psyllium Fiber in Children with Hypercholesterolemia,” The Journal of Pediatrics, Vol. 123, No. 1, 1993, pp. 24-29.

has been cited by the following article:

• TITLE: Dietary Fibers and Nutraceuticals for Primary Cardiovascular Prevention in Children and Adolescents: A Critical Review

  AUTHORS: Francesco Martino, Paolo Emilio Puddu, Giuseppe Pannarale, Francesco Barillà

  KEYWORDS: Cholesterol; Hyperlipemia; Childhood; Dietary Fibers; Nutraceuticals; Prevention

  JOURNAL NAME: Food and Nutrition Sciences, Vol.4 No.7A, June 25, 2013

  ABSTRACT: The roles of dietary fibers and nutraceuticals for primary prevention of cardiovascular disease from childhood are reviewed. Nutrition as an epigenetic modifier and the roles of endothelium, risk factors, epidemiological evidence and Mediterranean diet are critically analysed. Overfeeding in childhood can lead to the development of obesity and/or atherosclerosis in adult life. In particular, a high intake of nutrients affects the in utero programming with the adverse consequences of insulin resistance an endothelial dysfunction that lead to early atherosclerosis. Dietary fibers have important health benefits in childhood and research suggests that they may prevent obesity and lower blood cholesterol levels with a favourable impact on the risk of future cardiovascular disease incidence. However, it is for further studies to assess whether also in Southern European Countries, practicing Mediterranean diet as a normal habit, dietary fibers may contribute to modify the relatively low proportion of hyperlipemia observed in our population.