TITLE:
Zoon’s balanitis with mucinous metaplasia: A case report and review of literature
AUTHORS:
Jin-Ping Lai, Edward W. Cowen, Jere B. Stern, Leomar Y. Ballester, Emily Y. Chu, Rodolfo E. Chirinos, Richard W. Childs, Chyi-Chia Richard Lee
KEYWORDS:
Bone Marrow Transplant; Squamous Cell Carcinoma; Erythroplasia of Querat; Graft versus Host Disease
JOURNAL NAME:
Open Journal of Clinical Diagnostics,
Vol.3 No.2,
June
25,
2013
ABSTRACT: Mucinous metaplasia of the squamous epithelium of the glans penis is very rarely seen in the setting of Zoon’s balanitis. We report a case of 40 year old male with a past medical history of paroxysmal nocturnal hemoglobinuria, status-post allogeneic hematopoietic cell transplantation from an HLA-matched sibling 6 years prior to evaluation, complicated by oral and cutaneous chronic graft-versus-host disease. Mucinous metaplasia was confirmed by PAS and Mucin stains, and plasmacytosis was confirmed by immunohistochemistry for CD138 and MUM1 markers. Kappa and Lambda immunostains revealed a polyclonal pattern. The etiology of zoon’s balanitis as well as the significance of mucinous metaplasia in these setting are unclear and need to be further investigated.