TITLE:
Effects of Root Extracts from Panax ginseng C. A. Meyer (Araliaceae) of Different Ages on K562 Cells
AUTHORS:
Xunan Lyu, Yizhen Zhang, Qing Mu, Zhou Cheng, Jiakuan Chen, Wenju Zhang
KEYWORDS:
Panax ginseng; Root Extracts; Ages; K562 Cell Line
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.4 No.6,
June
25,
2013
ABSTRACT: It is well
accepted in China that elder ginsengs have more bioactivity and value than
younger ones. However, there is little research about the comparison of
beneficial effects of ginsengs with different ages. In this study, ginseng root
extracts (GRE) were extracted from ginsengs of 5, 8, 12, 14, and 16 years
old, respectively, using 55% ethanol and their effects on human leukemic K562 cells
within 48 hours were tested by using Cell Counting Kit-8. The results show that
there are significant increases in the cell viability of all the GRE groups
compared with Control group within 32 hours. Furthermore, the growth
curves of GRE groups were obviously distinct from each other. The cell
viability of 5-year-old and 8-year-old GRE groups kept a rapid increase while
that of 16-year-old GRE group showed a strong fluctuation within 28 hours. Our
results demonstrate that root extracts from ginsengs of different ages contain
different bioactivity constituents and have different effects on cell.