TITLE:
Cytokines, estradiol and progesterone in the plasma of women of reproductive age with pelvic inflammatory disease in remission
AUTHORS:
Aleksandr Trunov, Olga Obukhova, Olga Gorbenko, Alya Shvayk, Liliya Trunova
KEYWORDS:
Immune Response; Sex Hormones; Chronic Inflammation; Remission; Cytokines
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.6,
June
24,
2013
ABSTRACT: In the course of the study there were examined cytokine
levels of pro-inflammatory and anti-inflammatory activity (IL-1b, IL-4,
IL-6, IL-8, IL-10, IFN-g, G-GSF),
and also the levels of progesterone and estradiol in the blood serum with a view
to study the pathogenic characteristics of a chronic inflammatory process of
the pelvic organs in remission. It was shown that the remission of the disease
is characterized by the significant increase in the concentrations of
pro-inflammatory cytokines IL-6, IL-8, and also increase of inducers activation
of the immune response of the immune response (IL-4 and IFN-g), accompanied
by a decrease in the concentration of sex hormones. In women with chronic
inflammatory diseases of urogenital sphere in remission tested active immunological
process and violation of the synthesis of sex hormones. Revealed changes
predispose to the emergence disorders of reproductive health.