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V. Galimberti, B. F. Cole, S. Zurrida, G. Viale, A. Luini, P. Veronesi, P. Baratella, C. Chifu, M. Sargenti, M. Intra, O. Gentilini, M. G. Mastropasqua, G. Mazzarol, S. Massarut, J. R. Garbay, J. Zgajnar, H. Galatius, A. Recalcati, D. Littlejohn, M. Bamert, M. Colleoni, K. N. Price, M. M. Regan, A. Goldhirsch, A. S. Coates, R. D. Gelber and U. Veronesi, “International Breast Cancer Study Group Trial 23-01 Investigators, “Axillary Dissection versus No Axillary Dissection in Patients with Sentinel-Node Micrometastases (IBCSG 23-01): A Phase 3 Randomised Controlled Trial,” Lancet Oncology, Vol. 14, No. 4, 2013, pp. 297-305. doi:10.1016/S1470-2045(13)70035-4

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• TITLE: The Association between Sentinel Lymph Node Metastasis and Ki-67 Labeling Index

  AUTHORS: Yu Koyama, Hiroshi Ichikawa, Jun Sakata, Eiko Sakata, Kumiko Tatsuda, Miki Hasegawa, Chie Toshikawa, Naoko Manba, Mayuko Ikarashi, Toshifumi Wakai

  KEYWORDS: Breast Cancer; Sentinel Lymph Node; Molecular Subtypes; Ki-67 Labeling Index

  JOURNAL NAME: Advances in Breast Cancer Research, Vol.2 No.3, June 24, 2013

  ABSTRACT: Background: The purpose of this study was to elucidate the association between sentinel lymph node (SLN) metastasis and Ki67 labeling index and to elucidate whether Ki-67 was useful or not for prediction of SLN metastasis in breast cancer. Methods: We identified 343 invasive breast cancer patients with sentinel lymph node biopsy (SLNB) from 2003 to 2012. The association between SLN status and clinicopathological features, molecular subtypes and Ki-67 labeling index were evaluated. Results: SLN metastasis was detected in 79 patients (23.0%). SLN metastasis was significantly associated with clinical T-stage (p = 0.0003), lymphovascular involvement (LVI) (p 0.0001). Ki-67 labeling index of primary tumor was significantly lower in SLN positive patients (p = 0.0331), and Ki-67 cut-off point of 7.5% was useful for dividing SLN positive from negative (p = 0.0197). Conclusion: Low value of Ki-67 labeling index, in addition to progression of clinical T-stage and presence of LVI, is significantly associated with SLN metastasis, and it seems to be useful to consider Ki-67 labeling index for SLN metastasis prediction.