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Tuszynski, M.H. and Blesch, A. (2004) Nerve growth factor: From animal models of cholinergic neuronal degeneration to gene therapy in Alzheimer’s disease. Progress Brain Research, 146, 441-449. doi:10.1016/S0079-6123(03)46028-7

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• TITLE: Therapeutic approaches enhancing peripheral nerve regeneration

  AUTHORS: M. Egle De Stefano, Francesca Toni, Valerio D’ Orazi, Andrea Ortensi, Ada Maria Tata

  KEYWORDS: Nerve Fibers; Regeneration; Schwann Cells; Scaffolds; Cell Therapy

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.4 No.6A, June 20, 2013

  ABSTRACT: Peripheral nerve injury is a common occurrence and represents a major economic burden for society. The development of novel strategies to enhance peripheral nerve regeneration is, therefore, of great relevance. Conventional treatments include surgical repair of the damaged nerves for minor injuries, whereas autologous nerve grafts are required to recover longer interruptions. However, despite great surgical advances, functional recovery is often poor. Although it is well known that the peripheral nervous system has a greater regenerative capacity than the central nervous system and, considering the scientific advancements and knowledge in regenerative medicine, clinical applications appears still limited. This review provides an overview of the methodological approaches currently under study, aimed at enhancing peripheral nerve regeneration. In particular, tissue engineering, cell therapy and pharmacological approaches will be discussed.