TITLE:
Therapeutic approaches enhancing peripheral nerve regeneration
AUTHORS:
M. Egle De Stefano, Francesca Toni, Valerio D’ Orazi, Andrea Ortensi, Ada Maria Tata
KEYWORDS:
Nerve Fibers; Regeneration; Schwann Cells; Scaffolds; Cell Therapy
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.4 No.6A,
June
20,
2013
ABSTRACT: Peripheral
nerve injury is a common occurrence and represents a major economic burden for
society. The development of novel strategies to enhance peripheral nerve
regeneration is, therefore, of great relevance. Conventional treatments include
surgical repair of the damaged nerves for minor injuries, whereas autologous
nerve grafts are required to recover longer interruptions. However, despite
great surgical advances, functional recovery is often poor. Although it is well
known that the peripheral nervous system has a greater regenerative capacity
than the central nervous system and, considering the scientific advancements
and knowledge in regenerative medicine, clinical applications appears still
limited. This review provides an overview of the methodological approaches
currently under study, aimed at enhancing peripheral nerve regeneration. In
particular, tissue engineering, cell therapy and pharmacological approaches
will be discussed.