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Taguchi, K., Fujikawa, N., Komatsu, M., Ishii, T., Unno, M., Akaike, T., Motohashi, H. and Yamamoto, M. (2012) Keap1 degradation by autophagy for the maintenance of redox homeostasis. Proceedings of the National Academy of Sciences of USA, 109, 13561-13566. doi:10.1073/pnas.1121572109

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• TITLE: The orthodox therapy of cardiovascular diseases integrated by ozone-therapy is able to normalize the redox system

  AUTHORS: Velio Bocci, Emma Borrelli, Iacopo Zanardi, Valter Travagli

  KEYWORDS: Chronic Oxidative Stress; Ozone-Therapy; Nrf2-Keap1; Antioxidant Response; Integrative Medicine

  JOURNAL NAME: World Journal of Cardiovascular Diseases, Vol.3 No.3, June 20, 2013

  ABSTRACT: Cardiovascular diseases such as chronic limb ischemia, cardiomyopathies and stroke represent the first cause of death. Moreover, type-II diabetes, chronic obstructive pulmonary disease and age-related macular degeneration are also progressive pathologies complicated by a chronic inflammation that might be able to maintain progressive chronic oxidative stress. Orthodox medicine has provided excellent drugs which slow down the progression of these diseases but minimally reverse the oxidative stress conditions. Administration of antioxidants is unable to balance the oxidant excess. Today, all the biochemical and molecular mechanisms of ozone therapy have been clarified and it has been demonstrated that ozone therapy can reactivate the fundamental Nrf2 system and be able to restore the innate antioxidant defense mechanisms composed of several highly protective enzymes. This paper proposes to integrate the orthodox treatment with ozone therapy for improving clinical results.