TITLE:
The orthodox therapy of cardiovascular diseases integrated by ozone-therapy is able to normalize the redox system
AUTHORS:
Velio Bocci, Emma Borrelli, Iacopo Zanardi, Valter Travagli
KEYWORDS:
Chronic Oxidative Stress; Ozone-Therapy; Nrf2-Keap1; Antioxidant Response; Integrative Medicine
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.3 No.3,
June
20,
2013
ABSTRACT: Cardiovascular diseases such
as chronic limb ischemia, cardiomyopathies and stroke represent the first
cause of death. Moreover, type-II diabetes, chronic obstructive pulmonary disease and age-related macular degeneration
are also progressive pathologies complicated by a chronic inflammation that
might be able to maintain progressive chronic oxidative stress. Orthodox
medicine has provided excellent drugs which slow down the progression of these
diseases but minimally reverse the oxidative stress conditions. Administration
of antioxidants is unable to balance the oxidant excess. Today, all the
biochemical and molecular mechanisms of ozone therapy have been clarified
and it has been demonstrated that ozone therapy can reactivate the fundamental
Nrf2 system and be able to restore the innate antioxidant defense mechanisms
composed of several highly protective enzymes. This paper proposes to integrate
the orthodox treatment with ozone therapy
for improving clinical results.