Article citationsMore>>

T. Nakamura, H. Kakinuma, H. Umemiya, H. Amada, N. Miyata, K. Taniguchi, K. Bando and M. Sato, “Imidazole Derivatives as New Potent and Selective 20-HETE Synthase Inhibitors,” Bioorganic & Medicinal Chemistry Letters, Vol. 14, No. 2, 2004, pp. 333-336.

has been cited by the following article:

• TITLE: [1-(4-Nitrobenzyl)-2-butyl-4-chloro-1H-imidazol-5-yl]-4, 5-dihydro-1-phenyl-1H-pyrazole: Synthesis, Anti-Inflammatory and Analgesic Activities

  AUTHORS: S. Sreenivasa, B. J. Shankar

  KEYWORDS: Anti-Inflammatory; Analgesic; N-(nitrobenzyl)-imidazole aldehyde; Chloramine-T

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.3 No.2, June 20, 2013

  ABSTRACT: In the present investigation, series of Bis (heterocycle)s bearing pyrazoline in combination of the imidazole derivatives have been synthesized via 1,3-dipolar cycloaddition reactions of N-(nitrobenzyl)-imidazole nitrile imines with different dipolarophiles. All the newly synthesized compounds were characterized and screened for analgesic-anti-inflammatory activities and were compared with the standard drugs. The compounds exhibited excellent anti-inflammatory and analgesic activities. Out of the compounds studied 4b, 4d and 4g compounds shown statistically significant activity comparable to the standard drugs Ibuprofen and Aspirin at the same dose.