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D. H. Slee, S. J. Romano, J. Yu, T. N. Nguyen, J. K. John, N. K. Raheja, F. U. Axe, T. K. Jones and W. C. Ripka, “Development of Potent Non-Carbohydrate Imidazole-Based Small Molecule Selectin Inhibitors with Antiinflammatory Activity,” Journal of Medicinal Chemistry, Vol. 44, No. 13, 2001, pp. 2094-2107. doi:10.1021/jm000508c

has been cited by the following article:

• TITLE: [1-(4-Nitrobenzyl)-2-butyl-4-chloro-1H-imidazol-5-yl]-4, 5-dihydro-1-phenyl-1H-pyrazole: Synthesis, Anti-Inflammatory and Analgesic Activities

  AUTHORS: S. Sreenivasa, B. J. Shankar

  KEYWORDS: Anti-Inflammatory; Analgesic; N-(nitrobenzyl)-imidazole aldehyde; Chloramine-T

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.3 No.2, June 20, 2013

  ABSTRACT: In the present investigation, series of Bis (heterocycle)s bearing pyrazoline in combination of the imidazole derivatives have been synthesized via 1,3-dipolar cycloaddition reactions of N-(nitrobenzyl)-imidazole nitrile imines with different dipolarophiles. All the newly synthesized compounds were characterized and screened for analgesic-anti-inflammatory activities and were compared with the standard drugs. The compounds exhibited excellent anti-inflammatory and analgesic activities. Out of the compounds studied 4b, 4d and 4g compounds shown statistically significant activity comparable to the standard drugs Ibuprofen and Aspirin at the same dose.