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H. Mallesha, K. R. Ravikumar, K. Mantelingu and K. S. Rangappa, “Synthesis and Characterization of Model Ultimate Carcinogens/Metabolites Derived from Lead Tetraacetate Oxidation of Arylnitrones: 2’-Deoxyguanosine Adducts,” Synthesis, Vol. 2001, No. 10, 2001, pp. 1459-1461. doi:10.1055/s-2001-16096

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• TITLE: [1-(4-Nitrobenzyl)-2-butyl-4-chloro-1H-imidazol-5-yl]-4, 5-dihydro-1-phenyl-1H-pyrazole: Synthesis, Anti-Inflammatory and Analgesic Activities

  AUTHORS: S. Sreenivasa, B. J. Shankar

  KEYWORDS: Anti-Inflammatory; Analgesic; N-(nitrobenzyl)-imidazole aldehyde; Chloramine-T

  JOURNAL NAME: Open Journal of Medicinal Chemistry, Vol.3 No.2, June 20, 2013

  ABSTRACT: In the present investigation, series of Bis (heterocycle)s bearing pyrazoline in combination of the imidazole derivatives have been synthesized via 1,3-dipolar cycloaddition reactions of N-(nitrobenzyl)-imidazole nitrile imines with different dipolarophiles. All the newly synthesized compounds were characterized and screened for analgesic-anti-inflammatory activities and were compared with the standard drugs. The compounds exhibited excellent anti-inflammatory and analgesic activities. Out of the compounds studied 4b, 4d and 4g compounds shown statistically significant activity comparable to the standard drugs Ibuprofen and Aspirin at the same dose.