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S. P. Kerkar, L. Sanchez-Perez, S. Yang, Z. Borman, P. Muranski, Y. Ji, D. Chinnasamy, A. D. Kaiser, C. Hinrichs, C. S. Klebanoff, C. D. Scott, L. Gattinoni, R. A. Morgan, S. A. Rosenberg and N. P. Restifo, “Genetic Engineering of Murine CD8+ and CD4+ T Cells for Pre-clinical Adoptive Immunotherapy Studies,” Journal of Immunotherapy, Vol. 34, No. 4, 2011, pp. 343-352. doi:10.1097/CJI.0b013e3182187600

has been cited by the following article:

• TITLE: Melanoma Immunotherapy: Overcoming Obstacles to Augment Anti-Tumor Immune Responses

  AUTHORS: Kristian M. Hargadon

  KEYWORDS: Melanoma; Tumor Immunotherapy; Dendritic Cell; Tumor Antigen; T Cell; Vaccine; Adoptive Transfer

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.3 No.2A, June 20, 2013

  ABSTRACT: Melanoma is the most aggressive form of skin cancer and accounts for the vast majority of skin cancer-related deaths. Its ability to metastasize quickly, often before diagnosis, makes this cancer difficult to treat with traditional therapies. The identification of anti-melanoma immune responses in patients and the discovery of tumor antigens targeted by these immune responses have paved the way for immunotherapy as a novel approach to treating this cancer. In this review, the major immunotherapies targeting these melanoma tumor antigens are discussed. The advantages and limitations of peptide-, protein-, and gene-based vaccination maneuvers and adoptive cell transfer therapies are emphasized. Recent insights into melanoma immune evasion strategies are also highlighted, with particular focus on how our increasing knowledge of tumor/immune cell interactions is driving the development of novel immunotherapeutic strategies for the treatment of melanoma.