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B. N. Hangalapura, D. Oosterhoff, S. Aggarwal, P. G. Wijnands, R. van de Ven, S. J. Santegoets, M. P. van den Tol, E. Hoojiberg, A. Pereboev, A. J. van den Eertwegh, D. T. Curiel, R. J. Scheper and T. D. de Gruijl, “Selective Transduction of Dendritic Cells in Human Lymph Nodes and Superior Induction of High-Avidity Melanoma-Reactive Cytotoxic T Cells by a CD40-Targeted Adenovirus,” Journal of Immunotherapy, Vol. 33, No. 7, 2010, pp. 706-715. doi:10.1097/CJI.0b013e3181eccbd4

has been cited by the following article:

• TITLE: Melanoma Immunotherapy: Overcoming Obstacles to Augment Anti-Tumor Immune Responses

  AUTHORS: Kristian M. Hargadon

  KEYWORDS: Melanoma; Tumor Immunotherapy; Dendritic Cell; Tumor Antigen; T Cell; Vaccine; Adoptive Transfer

  JOURNAL NAME: Journal of Cosmetics, Dermatological Sciences and Applications, Vol.3 No.2A, June 20, 2013

  ABSTRACT: Melanoma is the most aggressive form of skin cancer and accounts for the vast majority of skin cancer-related deaths. Its ability to metastasize quickly, often before diagnosis, makes this cancer difficult to treat with traditional therapies. The identification of anti-melanoma immune responses in patients and the discovery of tumor antigens targeted by these immune responses have paved the way for immunotherapy as a novel approach to treating this cancer. In this review, the major immunotherapies targeting these melanoma tumor antigens are discussed. The advantages and limitations of peptide-, protein-, and gene-based vaccination maneuvers and adoptive cell transfer therapies are emphasized. Recent insights into melanoma immune evasion strategies are also highlighted, with particular focus on how our increasing knowledge of tumor/immune cell interactions is driving the development of novel immunotherapeutic strategies for the treatment of melanoma.