TITLE:
Acalculous Cholecystitis: An Unusual Manifestation of Cytomegalovirus Disease in Renal Transplant Recipient
AUTHORS:
Mostapha Habib Allah, Nour Houda Bassit, Wafaa Fadili, Inass Laouad
KEYWORDS:
CMV; Cholecystitis; Kidney; Renal; Transplant
JOURNAL NAME:
Open Journal of Nephrology,
Vol.3 No.2,
June
19,
2013
ABSTRACT: Background: Common clinical manifestations of cytomegalovirus (CMV) infection
include flu-like symptoms with fever, diarrhea, leukopenia, and elevated liver
enzymes. Diagnosis is made by detection of the virus by buffy-coat blood culture
or by polymerase chain reaction (PCR) analysis. Methods: Here we describe a women
renal transplant recipient who presented with acalculous cholecystitis with CMV
viremia, anemia and leucopenia tree months after she received a kidney from
cadaveric donor. Results: Retrospective analysis of peripheral blood by
PCR analysis was positive for CMV DNA. Treatement with Intravenous Ganciclovir
was started after diagnosis. The role of cholecystectomy in patients diagnosed
as having acalculous cholecystitis associated with systemic CMV disease remains
unclear. Conclusions: Because CMV infection is common in transplant
patients, the atypical manifestations of CMV should be considered in the differential
diagnosis of posttransplant complications. Detection of CMV DNA in the
peripheral blood by PCR analysis may help identify these patients.