TITLE:
Idiopathic Hypereosinophilic Syndrome Presenting as IgA Nephropathy with Nephrotic Range Proteinuria
AUTHORS:
Tajamul H. Shah, Ajaz N. Koul, Sonaullah Shah, Umar H. Khan, Parvaiz A. Koul, Fayaz A. Sofi, Mufti S., Rafi Ahmed Jan
KEYWORDS:
Idiopathic Hypereosinophilic Syndrome; Eosinophilia; Renal Involvement; Nephrotic Syndrome
JOURNAL NAME:
Open Journal of Nephrology,
Vol.3 No.2,
June
19,
2013
ABSTRACT: Idiopathic hypereosinophilic syndrome (IHES) is a disorder characterized
by increased eosinophil count (eosinophilia) along with organ dysfunction
secondary to organ infiltration of eosinophils and release of inflammatory markers [1-4], with no obvious cause for eosinophilia. The onset of symptoms
is insidious in most of the cases and eosinophilia is detected incidentally.
However, in others, the initial manifestations are severe and life-threatening
due to the rapid evolution of cardiac or neurologic complications [5]. Renal
involvement is rarely reported [6] in IHES. Herein we reported a case
of IHES with predominant renal involvement as nephrotic syndrome with focal
necrotizing IgA nephropathy.