TITLE:
New Greener Alternative for Biocondensation of Aldehydes and Indoles Using Lemon Juice: Formation of Bis-, Tris-, and Tetraindoles
AUTHORS:
Rammohan Pal
KEYWORDS:
Citrus limon Juice; Biocondensation; Aldehydes; Indoles; Aqueous Ethanol; Sonication; Bis-; Tris-; Tetraindoles
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.3 No.2,
June
14,
2013
ABSTRACT: This work
presents a new greener alternative for biocondensation of aldehydes and indoles
for the synthesis of bis- and tris(indolyl)methanes catalyzed by lemon juice (Citrus limon) in good yields under
ultrasound irradiation in aqueous ethanol. Various substituted aldehydes with
indoles under this reaction condition are elucidated. Also, tetraindolyl
compounds were prepared using terephthaldialdehyde by following the same
protocol. This method is an environmentally benign, efficient reaction, which requires shorter reaction time
and simple experimental and work-up procedures.