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M. C. Haigis, R. Mostoslavsky, K. M. Haigis, K. Fahie, D. C. Christodoulou, A. J. Murphy, D. M. Valenzuela, G. D. Yancopoulos, M. Karow, G. Blander, C. Wolberger, T. A. Prolla, R. Weindruch, F. W. Alt and L. Guarente, “SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic Beta Cells,” Cell, Vol. 126, No. 5, 2006, pp. 941-954. doi:10.1016/j.cell.2006.06.057

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• TITLE: The Sirtuins in Aging and Metabolic Regulation

  AUTHORS: T. C. LaGuire, S. K. Reaves

  KEYWORDS: Aging; Sirtuins; SIR-2; SIRT1; SIRT3; SIRT4; SIRT5; SIRT6; NF-kB; Metabolic Regulation

  JOURNAL NAME: Food and Nutrition Sciences, Vol.4 No.6, June 13, 2013

  ABSTRACT: Numerous theories of how and why aging occurs have been postulated but a definitive comprehensive explanation remains elusive. Attempts to unravel genetic details of aging resulted in the identification of a yeast gene known as Sir2 as a modulator of life span. Identification and characterization of mammalian Sir2 homologs followed and has catapulted aging research to exciting new levels. This review begins with basic definitions of aging and then describes some of the most common theories of the aging process. The review presents information related to the initial discovery of the Sirtuins and summarizes some of the recent advances in defining roles for Sirtuin family members. SIRT6 is discussed in greater detail because it is one of the best characterized of the mammalian Sirtuins and seems to be one of the most important in the aging process and metabolic regulation.