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Pocock, S.J., Wang, D., Pfeffer, M.A., Yusuf, S., McMurray, J.J., Swedberg, K.B., Ostergren, J., Michelson, E.L., Pieper, K.S. and Granger, C.B. (2006) Predictors of mortality and morbidity in patients with chronic heart failure. European Heart Journal, 27, 65-75. doi:10.1093/eurheartj/ehi555

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• TITLE: Predictors of survival among 60 patients with tissue proven primary cardiac amyloidosis

  AUTHORS: Hussam Suradi, Abbas Bitar, Merrill Benson, Mithilesh K. Das

  KEYWORDS: Amyloidosis; Cardiomyopathy

  JOURNAL NAME: Open Journal of Clinical Diagnostics, Vol.3 No.2, June 10, 2013

  ABSTRACT: Background: Cardiovascular involvement among patients with primary systemic amyloidosis (AL) is common and predicts poor prognosis. Different parameters have been used to predict outcome. We studied the prognostic significance of clinical, ECG and echocardiographic parameters of 60 patients with tissue proven primary cardiac amyloidosis. Method and Results: Records of 60 patients with primary amyloidosis and cardiac involvement documented by endomyocardial tissue biopsy were retrospectively evaluated. Patients mean age was 57.9 ± 10.2 years. 71.6% were male and 86.6% Caucasian. Patients’ median survival was 12.2 ± 4.4 months with only 50% of patients survived for more than 1 year. 60% of patients had CHF (NYHA II-IV). CHF (NYHA II-IV), IVS, LVPW and LVEF were significant on univariate survival analysis (p