TITLE:
Bordetella holmesii: Comparison of Two Isolates from Blood and a Respiratory Sample
AUTHORS:
Valérie Bouchez, Nicole Guiso
KEYWORDS:
Bordetella holmesii; Bacteremia; Respiratory Isolate
JOURNAL NAME:
Advances in Infectious Diseases,
Vol.3 No.2,
June
10,
2013
ABSTRACT: Interest in Bordetella holmesii is increasing, but very little is known about this bacterium, which can be
isolated from both blood and respiratory samples. In this study, we compared a B. holmesii isolate from the blood
sample of an adult with bacteremia with another isolate from a nasopharyngeal swab from an adult with
whooping cough syndrome. Genetic analysis was carried out, targeting relevant
genes, and virulence properties were studied in cellular and animal models. Our genomic analysis provided no evidence of
traits specific to either blood or respiratory isolates of B. holmesii. Neither isolate was cytotoxic to human tracheal
epithelial cells. Both isolates were only weakly invasive and they did not
persist within epithelial cells for less than 48 h.