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D. R. Murdoch, G. R. Corey, B. Hoen, J. M. Miro, V. G. Fowler Jr., A. S. Bayer, A. W. Karchmer, L. Olaison, P. A. Pappas, P. Moreillon, S. T. Chambers, V. H. Chu, V. Falco, D. J. Holland, P. Jones, J. L. Klein, N. J. Raymond, K. M. Read, M. F. Tripodi, R. Utili, A. Wang, C. W. Woods and C. H. Cabell, “Clinical Presentation, Etiology, and Outcome of Infective Endocarditis in the 21st Century: The International Collaboration on Endocarditis-Prospective Cohort Study,” Archives of Internal Medicine, Vol. 169, No. 5, 2009, pp. 463-473. doi:10.1001/archinternmed.2008.603

has been cited by the following article:

• TITLE: Do Cytokines Play a Role in Predicting Some Features and Outcome in Infective Endocarditis?

  AUTHORS: Maria Carmo Pereira Nunes, Izabella Rodrigues de Araújo, Andréa Teixeira de Carvalho, Letícia Alves Andrade, Marcio Henrique Lima Resende, José Luiz Padilha da Silva, Teresa Cristina Abreu Ferrari

  KEYWORDS: Infective Endocarditis; Inflammatory Cytokines; C-Reactive Protein

  JOURNAL NAME: Advances in Infectious Diseases, Vol.3 No.2, June 10, 2013

  ABSTRACT: Objective: This study aimed to measure the serum concentrations of several cytokines in patients with infective endocarditis (IE), and correlate them with the C-reactive protein serum levels, echocardiographic findings and infecting microorganisms. Methods: Forty-five patients with definite IE according to the Duke’s criteria were included in the study. Ten healthy blood donors formed the control group. Serum levels of interleukin (IL) 1β, IL-6, IL-8, IL-10, IL-12 and tumor necrosis factor-α (TNF-α) were measured and compared between the groups, and also with some clinical and laboratory parameters of IE. Results: Patients with IE had significantly higher serum concentrations of the inflammatory mediators than the control patients. Median IL-12 and IL-1β levels were higher in staphylococcal than streptococcal IE. Except for TNF-α, the levels of all the other cytokines correlated with the C-reactive protein concentrations. In multivariate analysis, IL-10 and IL-12 serum levels remained as independent factors associated with the C-reactive protein concentrations. There was a significant correlation between IL-10 concentration and vegetation length. Conclusion: The inflammatory serum cytokines levels were elevated in IE in comparison to healthy controls. C-reactive protein concentrations correlated with cytokines levels. IL-1β and IL-12 serum concentrations were higher in staphylococcal when compared to streptococcal IE. IL-10 levels were associated with vegetation size.