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Pockaj, B.A., Wasif, N., Dueck, A.C., Wigle, D.A., Boughey, J.C., Degnim, A.C., Gray, R.J., McLaughlin, S.A., Northfelt, D.W., Sticca, R.P., Jakub, J.W. and Perez, E.A. (2010) Metastasectomy and surgical resection of the primary tumor in patients with stage IV breast cancer: Time for a second look? Annals of Surgical Oncology, 17, 2419-2426. doi:10.1245/s10434-010-1016-1

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• TITLE: Evolutionary adaptations of human cancer for parasitic life

  AUTHORS: Sergey N. Rumyantsev

  KEYWORDS: Cancer Genealogy; Cancer Physiology; Cancer Reproduction; Hereditary Immunity; Make-Up of Cancer; Ontogeny of Cancer

  JOURNAL NAME: Open Journal of Immunology, Vol.3 No.2, June 5, 2013

  ABSTRACT: According to the xenogamous paradigm of cancer origin, pathogenesis and epidemic spread, human cancer is a disease caused by the appearance in the afflicted body of deviant multicellular structures whose cells are aggressive (gobble the afflicted body; grow and divide without respect to normal limits), invasive (invade and destroy adjacent tissues), metastatic (dispersed over embryogenesis at different locations in the body) and transmissible. The causative agent of the human disease has only just been identified as an ancient, unprecedentedly unique parasitic being that sustains itself at the expense of substances and energy derived from its victim’s body. Presented integrative discovery consists of a more systematic description of main adaptations of cancer causative agent to this specific way of life developed over its evolution. Focus is on the main stages of cancer existence including cancerous invasion of a human body, make-up of the parasite, its self-protection from the victim’s immune defense and regulatory management, disposition of cancer sub-units around afflicted body, the self-management of cancer and its nutrition, communication between dispersed cancer units, physiological synchronization between them, horizontal (reproductive) way of cancer transmission between humans.