TITLE:
Human Long Telomeres and Epigenetic Marks
AUTHORS:
María I. Vaquero-Sedas, Miguel A. Vega-Palas
KEYWORDS:
Telomeres; TERRA; Epigenetics; Human
JOURNAL NAME:
CellBio,
Vol.2 No.2,
June
5,
2013
ABSTRACT: We have read with interest the article “Telomere length
regulates TERRA levels through increased trimethylation of telomeric H3K9 and HP1α” by Arnoult and
colleagues [1]. This study focuses on human telomeric chromatin structure using
different techniques like Chromatin Immunoprecipitation (ChIP),
cytolocalization or RT-qPCR. However, it has been performed without taking into
consideration the presence of Interstitial Telomeric Sequences (ITSs) in the
human genome. Some of the conclusions of the article are undoubtedly clear but
there are others that might be explained in alternative ways, considering the
existence of ITSs. Following, we mention some comments that arise from this
interesting article.