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G. Bathori, L. Cervenak and I. Karadi, “Caveolae—An Alternative Endocytotic Pathway for Targeted Drug Delivery,” Critical Reviews in Therapeutic Drug Carrier Systems, Vol. 21, No. 2, 2004, pp. 67-95. doi:10.1615/CritRevTherDrugCarrierSyst.v21.i2.10

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• TITLE: Uptake of Cystatin by Melanoma Cells in Culture

  AUTHORS: Lauren Deady, James L. Cox

  KEYWORDS: Cystatin; Melanoma; Endocytosis; Fluorescent

  JOURNAL NAME: CellBio, Vol.2 No.2, June 5, 2013

  ABSTRACT: The cystatins are a super family of cysteine protease inhibitors which are ubiquitous in their biologic occurrence. Cystatin C, a type II cystatin, is primarily a secreted protein found in most biological fluids. Besides acting as inhibitors of cathepsin, the cystatins have been found to have some non-inhibitor related functions and multiple physiological roles. Much interest has been generated for the cystatins as metastasis “suppressor-like” proteins, as they have been shown to inhibit metastasis for multiple cancer types. The sites and actions of the cystatins related to tumor suppressor actions are still unclear, however. In this work, we have examined the uptake of cystatin by metastatic melanoma cells in culture. Our results indicate cystatin uptake is mediated by a non-canonical endocytotic pathway in B16 murine melanoma cells.