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M. P. Abbracchio, G. Burnstock, J. M. Boeynaems, E. A. Barnard and J. L. Boyer, “International Union of Pharmacology LVIII: Update on the P2Y G Protein-coupled Nucleotide Receptors: From Molecular Mechanisms and Pathophysiology to Therapy,” Pharmacological Reviews, Vol. 58, No. 3, 2006, pp. 281-341. doi:10.1124/pr.58.3.3

has been cited by the following article:

• TITLE: Bacterial UDP-Glucose Hydrolases and P2 Receptor-Mediated Responses to Infection: A Commentary

  AUTHORS: Ifor R. Beacham, John P. Headrick

  KEYWORDS: UDP-Glucose Hydrolase; P2Y14 Receptor; Virulence Factor; Salmonella enterica; E. coli

  JOURNAL NAME: Advances in Infectious Diseases, Vol.3 No.2, June 5, 2013

  ABSTRACT: UDP-glucose hydrolases are a group of relatively little known membrane-bound or periplasmic enzymes found in Salmonella enterica and E. coli. UDP-glucose is an agonist for a specific P2 receptor (P2Y14) found on epithelial cells and cells associated with innate immunity. It is also recognised as a ‘danger signal’. Cells respond to mechanical damage by releasing UDP-glucose which activates P2Y14 to trigger an innate immune response; it is postulated that a similar response to bacterial infection may be protective against infection. However, the UDP-glucose hydrolases may constitute virulence factors able to abrogate this response by degradation of the released UDP-glucose.