TITLE:
Regeneration from a Cell Biological Perspective—Fascinating New Insights and Paradigms
AUTHORS:
Bor Luen Tang
KEYWORDS:
Inflammation; Induced Pluripotent Stem (iPS) Cells; Progenitor/Stem Cells; Regeneration; Reprogramming; Wnt
JOURNAL NAME:
CellBio,
Vol.2 No.2,
June
4,
2013
ABSTRACT: Regeneration research is more focused on translational
values. However, lying at its very foundation is an understanding of
how tissues and organs repair and renew themselves at the cellular level. The
past decade has witnessed paradigm changing advances in regenerative biology,
many of these stems from novel insights into stemness, pluripotency, cell death
and their related intra- and inter-cellular biochemical and molecular processes.
Some of these new insights are highlighted in the paragraphs that follow. We
now have a much better understanding of how regeneration occurs in lower
organisms. We have also discovered tools and means of nuclear reprogramming to
generate induced pluripotency and changes in cell fate in mammalian models.
With further research, there is reasonable hope that various obstacles of
regeneration in humans can be better understood and tackled. As regeneration
research enters a new era, CellBio welcomes
timely review articles and original papers on the theme of “The Cell Biology of
Regeneration”.