TITLE:
Evaluating the Efficacy of Remifentanil-Propofol versus Isoflurane in Reducing Blood Loss with Considering Depth of Anesthesia during Endoscopic Sinus Surgery
AUTHORS:
Mohammad Ali Haghbin, Hossein Hakimzadeh, Mohammad Shabani
KEYWORDS:
Isoflurane; Propofol; Remifentanil; Blood Loss; Endoscopic Sinus Surgery
JOURNAL NAME:
Neuroscience and Medicine,
Vol.4 No.2,
June
3,
2013
ABSTRACT: Several methods have been suggested to
decrease bleeding during surgery, one of which is the usage of hypotensive
anesthetic agents. Endoscopic Sinus Surgery (ESS) is one of the surgeries which
need a clear field and the amount of bleeding profoundly impacts the ability of
surgeons. Current study was designed to evaluate the effect of remifentanil
combined with propofol versus Isoflurane on blood loss during ESS and its
possible interaction with Depth of Anesthesia. Fifty one patients comprising 15
females and 36 males undergoing ESS were chosen for this study. One group received
propofol and remifentanil to induce and maintain anesthesia and the second
group received Isoflurane. Mean Arterial Blood Pressure (MAP), Depth of
Anesthesia and total blood loss were recorded for the patients of both group.
Data were analyzed using t-test, Repeated Measures ANOVA and Pearson’s
correlation. P 0.05 was considered statistically
significant. Both agents induced hypotension during surgery. No significant
difference was observed in total blood loss between two groups. DA was
decreased in both groups, but no significant correlation was found between DA
and MAP or DA and blood loss. There is no significant difference between
remifentanil combined with propofol and Isoflurane in decreasing blood loss
during ESS, thus we suggest usage of hypotensive anesthetic agent regardless of
its type is ESS.