TITLE:
Advanced Breast Angiosarcoma Completely Responding to Chemotherapy
AUTHORS:
Zhiguo Luo, Qian Wang, Wei Peng, Jianhua Chang, Xichun Hu, Xiaonan Hong
KEYWORDS:
Angiosarcoma; Lung Metastases; Gemcitabine; Chemotherapy
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.4,
May
31,
2013
ABSTRACT: Introduction: For patients with anthracycline-resistant metastatic angiosarcoma, currently there is no available standard for second-line therapy and there is a need for novel effective regimens to improve response rates. Case report: We reported here about a case of a primary angiosarcoma of both breasts in a 34-year-old woman presenting lung metastases. At the completion of 3 cycles of the MAID regimen including mesna, adriamycin, ifosfamide and dacarbazine, CT showed progression of the disease (PD). Subsequently second-line chemotherapy was started using GVP regimen consisting of gemcitabine, vincristine and cisplatin. Complete response (CR) of the lung metastases was achieved after 6 treatment cycles. Conclusion: In the absence of an effective therapy among patients with anthracycline-resistant metastatic breast angiosarcoma, a GVP chemo-regimen can be performed as a selective option.