TITLE:
Nephrotoxicity Evaluation in Outpatients Treated with Cisplatin-Based Chemotherapy Using a Short Hydration Method
AUTHORS:
Songül Tezcan, Fikret Vehbi Izzettin, Mesut Sancar, Perran Fulden Yumuk, Serdar Turhal
KEYWORDS:
Cisplatin; Nephrotoxicity; Clinical Pharmacy; Oncology Pharmacy; Chemotherapy
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.4 No.3,
May
31,
2013
ABSTRACT: Background: To evaluate cisplatin-induced nephrotoxicity in outpatients receiving
chemotherapy with cisplatin alone or in combination with other agents using a
short hydration method. Methods: Forty-nine patients enrolled in the
study were monitored during 3 cycles of chemotherapy. Cisplatin was given in
1000 mL of 0.9% NaCl solution for 90 min as an intravenous infusion. Renal
parameters were evaluated before and after each chemotherapy cycle, and 6 weeks
after the completion of treatment. Results: Blood urea nitrogen,
creatinine, and cystatin C levels increased significantly during the 3 cycles of
chemotherapy, whereas sodium and potassium levels decreased significantly.
Magnesium and calcium levels decreased only during the second cycle of chemotherapy.
Significant increases in uric acid level were observed during the 1st and 3rd cycles, and 6 weeks after the completion
of treatment. Conclusions: The method used in our study shows minimal
changes in renal functions. To effectively monitor nephrotoxicity, renal
parameters and electrolyte levels should be measured before and after each cisplatin based
chemotherapy cycle. More investigations are required to evaluate this method with higher doses of cisplatin.