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E. Matthew, P. Andreason, R. E. Carson, P. Herscovitch, K. Pettigrew, R. Cohen, C. King, C. E. Johanson, and S. M. Paul, (1993) Reproducibility of resting cerebral blood flow measurements with H215O positron emission tomography in humans, Journal of Cerebral Blood Flow and Metabolism, 13, 748-754.

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• TITLE: Changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging: normal volunteers examined during normal breathing and hyperventilation

  AUTHORS: Ronnie Wirestam, Christian Engvall, Erik Ryding, Stig Holtas, Freddy Stahlberg, Peter Reinstrup

  KEYWORDS: Magnetic Resonance Imaging; Perfusion; Cerebral Blood Flow; Mean Transit Time; Hypocapnia

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.2 No.4, August 14, 2009

  ABSTRACT: Global cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) de-creased during hyperventilation in all volun-teers (average decrease 29%), and the corre-sponding global CBF estimates were 73±19ml/ (min100g) during normal breathing and 52± 7.9ml/(min100g) during hyperventilation (mean ±SD, n=8). Furthermore, the hypocapnic condi-tions induced by hyperventilation resulted in a prolongation of the global mean transit time (MTT) by on average 14%. The observed CBF estimates appeared to be systematically over-estimated, in accordance with previously pub-lished DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.