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H. Ito, M. Ibaraki, I. Kanno, H. Fukuda, and S. Miura, (2005) Changes in the arterial fraction of human cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography, Journal of Cerebral Blood Flow and Metabolism, 25, 852-857.

has been cited by the following article:

• TITLE: Changes in cerebral perfusion detected by dynamic susceptibility contrast magnetic resonance imaging: normal volunteers examined during normal breathing and hyperventilation

  AUTHORS: Ronnie Wirestam, Christian Engvall, Erik Ryding, Stig Holtas, Freddy Stahlberg, Peter Reinstrup

  KEYWORDS: Magnetic Resonance Imaging; Perfusion; Cerebral Blood Flow; Mean Transit Time; Hypocapnia

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.2 No.4, August 14, 2009

  ABSTRACT: Global cerebral perfusion parameters were measured using dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) in eight healthy volunteers examined during normal breathing and spontaneous hyperventilation. DSC-MRI-based cerebral blood flow (CBF) de-creased during hyperventilation in all volun-teers (average decrease 29%), and the corre-sponding global CBF estimates were 73±19ml/ (min100g) during normal breathing and 52± 7.9ml/(min100g) during hyperventilation (mean ±SD, n=8). Furthermore, the hypocapnic condi-tions induced by hyperventilation resulted in a prolongation of the global mean transit time (MTT) by on average 14%. The observed CBF estimates appeared to be systematically over-estimated, in accordance with previously pub-lished DSC-MRI results, but reduced to more reasonable levels when a previously retrieved calibration factor was applied.