TITLE:
Evaluation of 4 different bone graft substitutes and autogenous bone grafting in root-end resection osteotomies after retrograde root-filling with Intermediate Restorative Material (IRM): An experimental study in dogs
AUTHORS:
Dan-Åke Wälivaara, Peter Abrahamsson
KEYWORDS:
Bone Graft Substitutes; Periapical Surgery; Autogenous Bone; Intermediate Restorative Material
JOURNAL NAME:
Open Journal of Stomatology,
Vol.3 No.2,
May
28,
2013
ABSTRACT: Purpose: To investigate the
periapical tissue response after root end filling with intermediate restorative material (IRM) and filling of the root-end resection
bone defects with autogenous bone or a bone graft substitute in comparison to
empty controls. Materials and Methods: Vital roots of the second, third and
fourth mandibular premolars in six healthy mongrel dogs were apectomized. The
root canals were prepared and sealed with IRM following a standardized
surgical procedure. The resection bone defects were either filled with autogenous bone (PB) or one of the bone
graft substitutes; CERAMENTTM|BONE VOID FILLER, ChronOS?, TigranTM PTG, Easygraft? CLASSIC or left empty. After 120 days the animals were
sacrificed and the specimens were analyzed radiologically and histologically.
Kruskal-Wallis and Mann-Whitney tests were performed for statistical
evaluation. Results: 34 sections were analyzed histologically. The evaluation
revealed a variation in the outcome amongst the tested options, regarding reestablishment
of the periapical bone healing and inflammatory infiltration in the sections.
According to the tested variables, there was no statistical significant
difference between the materials when comparing all groups as a whole. When
comparing individual materials to each other there was statistical differences
among some of the tested materials. Conclusion:
The healing outcome after periapical surgery of a five-wall resection defect
could not be increased by infill with autogenous bone or bone graft substitutes.
The most important factor for the healing outcome in periapical surgery is the
quality of the root-end sealing. The healing outcome after some of the tested
bone substitutes, might be improved by longer healing time.