TITLE:
Absence of albuminuria in type 2 diabetics with classical diabetic nephropathy: Clinical pathological study
AUTHORS:
Pooja Budhiraja, Bijin Thajudeen, Mordecai Popovtzer
KEYWORDS:
Kimmelstiel-Wilson Lesions; Diabetes Mellitus; Nephropathy; Albuminuria
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.5A,
May
28,
2013
ABSTRACT: Background:
Diabetic nephropathy is the most common cause of chronic kidney disease and
the number afflicted patients continues to rise. The presence of proteinuria
has been considered as a prerequisite for the diagnosis of diabetic
nephropathy. But one third to one half of type 2 diabetics with CKD have no proteinuria and the pathology of non proteinuric CKD in this group remains unclear
as renal biopsy is commonly not performed in these patients. The present
study addresses the question: Can a classical diabetic nephropathy occur in the
absence of proteinuria? Method: We examined renal biopsies of subjects who
underwent nephrectomy from 1999 to 2009 for renal cancer, had eGFR