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Inoue, H., Ono, K., Masuda, W., Morimoto, Y., Tanaka, T., Yokota, M. and Inenaga, K. (2006) Gender differences in unstimulated whole saliva flow rate and salivary gland sizes. Archives of Oral Biology, 51, 1055-1060. doi:10.1016/j.archoralbio.2006.06.010

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• TITLE: Salivary flow rates, per se, may not serve as consistent predictors for dental caries

  AUTHORS: Cynthia P. Trajtenberg, Juliana A. Barros, Shalizeh A. Patel, Leslie Miles, Charles F. Streckfus

  KEYWORDS: Salivary Glands; Saliva; Caries; Aging; Medications

  JOURNAL NAME: Open Journal of Stomatology, Vol.3 No.2, May 28, 2013

  ABSTRACT: Background: This clinical study evaluated the effects of salivary flow rate, age, race, health status and medications on the incidence of caries. Methods:Cauca-sian and African-American men and women (n = 501), aged 22-93 years participated in the study. Stimulated (S) and unstimulated (U) parotid (P) and submandibular glands (SM) salivary secretions were collected. Stimulated whole saliva (SWS) was collected as control. Glandular stimulation was achieved using 2% citric acid at 30-second intervals to the dorsal surface of the tongue. Salivary flow rates (SFR) were calculated by total weight of saliva divided by 5 minutes and expressed in ml/minute. Coronal caries were scored using the NIDR DMFS index. Carious lesions were classified according to tooth surfaces by a calibrated single examiner. Spearman correlation coefficients were calculated to determine the association between SFR with age and percentage of carious teeth. Multiple regression analyses were calculated at (p