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Hebert, S.S., Horre, K., Nicolai, L., Papadopoulou, A.S., Mandemakers, W., Silahtaroglu, A.N., et al. (2008) Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimers disease correlates with increased BACE1/beta-secretase expression. Proceedings of the National Academy of Sciences of the United States of America, 105, 64156420. doi:10.1073/pnas.0710263105

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• TITLE: Identification of regulatory sequence signatures in microRNA precursors implicated in neurological disorders

  AUTHORS: Sayak Ganguli, Sasti Gopal Das, Hirak Jyoti Chakraborty, Sohini Gupta, Abhijit Datta

  KEYWORDS: Neurological Diseases; Regulatory Motif Signatures; Parkinson’s Disease; Alzheimer’s Disease; Huntington Disease

  JOURNAL NAME: Advances in Bioscience and Biotechnology, Vol.4 No.5A, May 27, 2013

  ABSTRACT: MicroRNAs have emerged as one of the major classes of non-coding RNAs. Recent reports have placed them in high abundance in the nervous system, having key roles in development. Neurological disorders such as Parkinson’s disease, Alzheimer’s disease as well as Huntington disease have also been studied and several microRNAs associated with diseases pathogenesis have been identified. Various such findings indicate differential expression levels of many of these microRNAs. Such changes in the expression levels not only indicate towards a control of the biogenesis of these microRNAs but also indicate towards critical yet unelucidated roles of regulatory proteins, which probably act in concert to control the production or maturation of these molecules. In this work, a collection of overrepresented regulatory motif signatures were identified in the DNA and RNA sequences of the precursor microRNAs. The identification of such regulatory sequence signatures promises to provide new insights into many facets of microRNA regulation and neurological disorders.