TITLE:
Protective effects of polar lipids and redox-active compounds from marine organisms at modeling of hyperlipidemia and diabetes
AUTHORS:
Alexander M. Popov, Olga N. Krivoshapko
KEYWORDS:
PUFA; Polyphenols; 1, 4-Naphtoquinones; Diabetes; Hyperlipidemia
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.5,
May
25,
2013
ABSTRACT: Cardiovascular
diseases and diabetes mellitus are leading causes of mortality in modern
society. The search for a novel effective remedy represents an important task
for modern medicine. A total mixture of phospho- and glycolipids from sea
macrophytes Sargassum pallidum, Ulva fenestrata, Zostera marina was separated and the fatty acid composition was determined. The biological activity of the mixtures of polar lipids and natural redox-active compounds (echinochrome
A from the flat sea urchin Scaphechinus
mirabilis and a polyphenolic complex from the sea grass Zostera marina) was studied under
conditions of impairments of carbohydrate
and lipid metabolism. Doses and compositions of mixtures of pola lipids
and redox-active compounds possessing high corrective activity were optimized in mice with the
experimental model of hyperlipidemia and diabetes. Based on these results
possible mechanisms of the effects of polar lipids containing various polyunsaturated
fatty acids and the investigated redox-active
compounds (echinochrome A, rosmarinic acid, luteolin and
its sulphate conjugates) have been proposed. The developed compositions may
be used for creation of new biologically active additives and remedies.