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Barbier, O., Torra, I.P., Duguay, Y., Blanquart, C., Fruchart, J.C., Glineur, C. and Staels, B. (2002) Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, 22, 717-722. doi:10.1161/01.ATV.0000015598.86369.04

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• TITLE: Protective effects of polar lipids and redox-active compounds from marine organisms at modeling of hyperlipidemia and diabetes

  AUTHORS: Alexander M. Popov, Olga N. Krivoshapko

  KEYWORDS: PUFA; Polyphenols; 1, 4-Naphtoquinones; Diabetes; Hyperlipidemia

  JOURNAL NAME: Journal of Biomedical Science and Engineering, Vol.6 No.5, May 25, 2013

  ABSTRACT: Cardiovascular diseases and diabetes mellitus are leading causes of mortality in modern society. The search for a novel effective remedy represents an important task for modern medicine. A total mixture of phospho- and glycolipids from sea macrophytes Sargassum pallidum, Ulva fenestrata, Zostera marina was separated and the fatty acid composition was determined. The biological activity of the mixtures of polar lipids and natural redox-active compounds (echinochrome A from the flat sea urchin Scaphechinus mirabilis and a polyphenolic complex from the sea grass Zostera marina) was studied under conditions of impairments of carbohydrate and lipid metabolism. Doses and compositions of mixtures of pola lipids and redox-active compounds possessing high corrective activity were optimized in mice with the experimental model of hyperlipidemia and diabetes. Based on these results possible mechanisms of the effects of polar lipids containing various polyunsaturated fatty acids and the investigated redox-active compounds (echinochrome A, rosmarinic acid, luteolin and its sulphate conjugates) have been proposed. The developed compositions may be used for creation of new biologically active additives and remedies.