TITLE:
Evaluation of Biological Effects of Nanosystems of Directed Transport in Experiments in Vivo and Their Application Possibilities in Anti-Tumor Therapy
AUTHORS:
Vasyl F. Chekhun, Lesia A. Naleskina, Liudmila Z. Polishchuk, Igor M. Todor, Dmytro V. Demash, Natalia Yu. Lukianova
KEYWORDS:
Oncology; Nanocomposite; Static Magnetic Field; Cisplatin; Anti-Tumor Activity; Guerin Carcinoma
JOURNAL NAME:
Advances in Nanoparticles,
Vol.2 No.2,
May
25,
2013
ABSTRACT: The aim of the investigations was to evaluate benefits of the directed transport system - a nanocomposite, based on cisplatin and magnetite combined with local action of constant magnetic field on the tumor, in experiments in vivo in animals with transplantable Guerin carcinoma. Animals were divided into 5 groups according to the type of agent. We showed that nanocomposite in combination with static magnetic field exercises more prominent anti-tumor activity than cisplatin alone. It should be noted that regardless of the therapeutic agent, in Guerin carcinoma we observed