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Fujita, K., Nozaki, Y., Yoneda, M., Wada, K., Takahashi, H., Kirikoshi, H., Inamori, M., Saito, S., Iwasaki, T., Terauchi, Y., Maeyama, S. and Nakajima, A. (2010) Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. Alcoholism: Clinical and Experimental Research, 34, 18-24. doi:10.1111/j.1530-0277.2008.00756.x

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• TITLE: Fermented papaya preparation halts the progression of non-alcoholic steatohepatitis in rats

  AUTHORS: Shinki Murakami, Fusako Takayama, Toru Egashira, Mitsuko Imao, Akitane Mori

  KEYWORDS: Fermented Papaya Preparation; Non-Alcoholic Steatohepatitis; Oxidative Stress; Antioxidant Activity; Inflammation

  JOURNAL NAME: Journal of Biophysical Chemistry, Vol.4 No.2, May 24, 2013

  ABSTRACT: Non-alcoholic steatohepatitis (NASH) can progress to cirrhosis or hepatocellular carcinoma. Oxidative stress is implicated in NASH progression. Fermented papaya preparation (FPP) has oxygen radical scavenging activity and is effective in oxidative stress-related diseases. We investigated the effects of FPP on NASH progression using a rat NASH model. Plasma biochemical parameters and lipid peroxidation in the liver were elevated in NASH rats. Histologically, the liver of NASH rats showed liver fibrosis, mitochondrial dysfunction and over-expression of microsomal CYP2E1. Myeloperoxidase activity and nuclear factor-kappaB activation were also markedly increased in NASH. Oral administration of FPP ameliorated these changes in NASH rats. These results suggest that FPP halts NASH progression through its anti-oxidative and antiinflammatory properties.