TITLE:
Fermented papaya preparation halts the progression of non-alcoholic steatohepatitis in rats
AUTHORS:
Shinki Murakami, Fusako Takayama, Toru Egashira, Mitsuko Imao, Akitane Mori
KEYWORDS:
Fermented Papaya Preparation; Non-Alcoholic Steatohepatitis; Oxidative Stress; Antioxidant Activity; Inflammation
JOURNAL NAME:
Journal of Biophysical Chemistry,
Vol.4 No.2,
May
24,
2013
ABSTRACT: Non-alcoholic
steatohepatitis (NASH) can progress to cirrhosis or hepatocellular carcinoma.
Oxidative stress is implicated in NASH progression. Fermented papaya
preparation (FPP) has oxygen radical scavenging activity and is effective in
oxidative stress-related diseases. We investigated the effects of FPP on NASH
progression using a rat NASH model. Plasma biochemical parameters and lipid
peroxidation in the liver were elevated in NASH rats. Histologically, the liver
of NASH rats showed liver fibrosis, mitochondrial dysfunction and over-expression
of microsomal CYP2E1. Myeloperoxidase activity and nuclear factor-kappaB activation
were also markedly increased in NASH. Oral administration of FPP ameliorated
these changes in NASH rats. These results suggest that FPP halts NASH
progression through its anti-oxidative and antiinflammatory properties.