TITLE:
Clear cell carcinoma of salivary gland type presenting as an endotracheal polypoid tumor
AUTHORS:
Kazuhiro Tabata, Michiyo Higashi, Shinichi Kitajima, Ikumi Kitazono, Tsubasa Hiraki, Tsunayuki Otsuka, Masaya Aoki, Kazuhiro Wakita, Hirofumi Nakayama, Suguru Yonezawa, Junya Fukuoka
KEYWORDS:
Clear Cell Carcinoma; Salivary Gland; Lung Primary; Histological Feature
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.2 No.2,
May
24,
2013
ABSTRACT: A 66-year-old woman presented
with a 2-year history of asthma has progression of dyspnea within a week, and a
computed tomography (CT) revealed an endotracheal tumor at level of aortic
arch. The resected tumor, measured by 18 × 12 × 10 mm, has histologically malignant features including frank invasion
with desmoplastic stroma and foci of necrosis. Presence of glycogen and
mucin was confirmed by periodic acid-Schiff (PAS) and diastase PAS staining. Immunohistochemically, the tumor cells were diffusely positive for cytokeratin
(CK) 7 and AE1/3, focally positive for CK5/6 and CK14, but negative for CK20. Thyroid transcription factor-1
(TTF-1), Napsin A, and SP-A, indicating lung parenchymal origin were
all negative. Other muscular markers, neuroendocrine markers, renal cell
carcinoma markers, and markers related to perivascular epithelioid cell
tumors were all negative. Postoperative systemic examination suggests no
primary tumor outside the lung. The follow up was
excellent being recurrence free for 14 months in spite of the positive surgical
margin by the tumor cells. This is a first report of rare neoplasm, clear cell carcinoma of salivary gland type, presenting as an endotracheal mass.