TITLE:
Promethazine-Tetraphenyl Boron(III) Modified Carbon Paste Electrode for the Determination of Promethazine Hydrochloride
AUTHORS:
Sayed Sayed Badawy, Sherif Abo El Seoud El Said
KEYWORDS:
Carbon Paste Electrode; Ion Pair; Promethazine Hydrochloride; Phenergan (Syrup)
JOURNAL NAME:
American Journal of Analytical Chemistry,
Vol.4 No.5,
May
23,
2013
ABSTRACT: Promethazine modified carbon paste ion selective
electrode has been prepared, based on the ion pair of promethazine hydrochloride
Pm.Cl with sodium tetraphenyl boron(III) Pm-TPB dissolved in dioctyl phthalate
DOP as a pasting liquid. The electrode showed the linear response with mean
calibration graph slope of 58 mV/decade at 25℃; at a concentration range and
a lower detection limit of 1 × 10-5 -6 × 10-2 M and 8 × 10-6 M promethazine hydrochloride, respectively. The
change of pH of the tested solution within the range 4.2 -6.8 did not
affect the electrode performance. The electrode showed a
very good selectivity toward Pm+ cations with respect to a large number of
organic and inorganic cations and compounds. The standard addition and
potentiometric titration methods were applied for the determination of promethazine
hydrochloride in pure solution and in pharmaceutical preparations with anaverage
recovery range of 97.3% -101.4% and a mean relative standard deviation (RSD)
of 0.35% -1.83 % which were of comparable accuracy and precision to the
previously reported works.