TITLE:
The Potential Effect of Special Formulas on Cirrhotic Rats
AUTHORS:
Enayat M. Hassan, Ghada M. El-Kherbawy, Mona A. M. Ali, Omaima M. Dewidar
KEYWORDS:
Liver Cirrhosis; CCl4; Formulas; Liver Function; Histopathological; Hepatoprotective
JOURNAL NAME:
Food and Nutrition Sciences,
Vol.4 No.5,
May
23,
2013
ABSTRACT: Liver protective effect of special formulas
(1 and 2) was assessed against carbon tetra chloride (CCl4) which
induced liver damage in Wister albino rats. The two prepared formulas reduced
the changes in body weight and liver weight caused by CCl4 in rats. The toxicity of CCl4 is related to loss in body weight and increase in liver weight in rats. The weight ratios of liver to body weight (LW/BW)
significantly increased in rats treated with CCl4 followed by other
groups. Formulas 1 and 2 could play an important role in improvement of hematological indices in
liver cirrhosis rats. Feeding treated rats on special formulas showed improvement in liver function compared to rats fed
on basal diet, reflected by significant reduction of the activity
of transaminases (ALT and AST), alkaline phosphatase (ALP) and total bilirubin. There was a significant increase in total protein, albumin and globulin in
serum. Significant increase in liver weight in rats treated with CCl4. There are no histopathological changes
in all groups under study except for group 4 (CCl4 treated rats fed
on basal diet) which orally administrated with CCl4 and had
congestion of central vein and hepatic sinusoids.