TITLE:
Storage and Timed Release of Acetaminophen from Porous Carbonaceous Materials
AUTHORS:
Sarah E. McCary, Thomas R. Rybolt
KEYWORDS:
Carbon Powders; Drug Release; Adsorption of Acetaminophen; Mesoporosity; Storage of Acetaminophen
JOURNAL NAME:
Open Journal of Physical Chemistry,
Vol.3 No.2,
May
23,
2013
ABSTRACT: Six carbon powders with
varied surface areas and porosities were used to store and release
acetaminophen (ACT). A 10 mg/mL solution of acetaminophen in phosphate buffer
solution (pH = 7.0) at 25℃ with exposure to carbon powder for 72 hours was
used to drive the maximum loading of acetaminophen into the powders. Carboxen
1012 (BET surface area of1500 m2/g)
powder exhibited the greatest maximum adsorption of ACT (up to 62% by mass).
The maximum ACT adsorption was correlated with surface area and porosity. The
most effective carbon powders for binding ACT were ones containing high
mesopore volumes. Loaded carbon powder was separated from the ACT solution and
then phosphate buffer solution (pH = 7.0) was combined with the loaded carbon powder and
ACT absorbance readings at 243 nm were taken over time. The various carbon
powders were able to release a portion of the ACT that they originally adsorbed.
The Carboxen 1012 powder displayed the greatest ACT release with a rapid
initial release followed by a steady but slightly declining release over a time
period of 2 to 11 weeks. The results were supportive of mesoporous carbons such
as Carboxen 1012 being suitable for drug loading and release.