TITLE:
No association between the GSTM1 and GSTT1 polymorphism and endometrial cancer risk: A meta-analysi
AUTHORS:
Marce-Amara Kpoghomou, Fatch W. Kalembo, Joella Eldie Soatiana
KEYWORDS:
GSTM1; GSTT1; Polymorphism; Endometrial Cancer; Meta-Analysis
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.3 No.4,
May
23,
2013
ABSTRACT: Purpose:
A number of case-control studies have been conducted to investigate the
association of glutathione S-transferase (GST) genetic polymorphisms and endometrial
carcinoma risk. However, these studies have yielded contradictory results. We
therefore performed a meta-analysis to derive a more precise estimation of
the association between polymorphisms on GSTM1, GSTT1 and endometrial
carcinoma. Methods: Identification of relevant studies was carried out
through a search in the following databases Medline, EMbase andChinaNational
Knowledge International (CNKI) up to March. 2013. All case-control studies
that investigated the association between GS-TM1 and GSTT1 gene polymorphisms
and risk of endometrial cancer were included in the study. The pooled odds
ratio (OR) was used for analyses of results and the corresponding 95% confidence
intervals (CI) were estimated. Result: Six published case-control studies of
association between the GSTM1 and GSTT1 polymorphism and endometrial cancer
risk covering 3558 subjects were included in the metaanalysis, but the
results indicated that the null genotypes of GSTM1 and GSTT1 polymorphisms
were not associated with a significantly increased risk of endometrial cancer
(for GSTM1: OR = 0.99; 95% CI, 0.86 - 1.4;
for GSTT1: OR = 0.96; 95% CI, 0.80 - 1.14, respectively). Conclusion:
This meta-analysis suggests that GSTM1 and GSTT1 polymorphism may not be
associated with increased risk of endometrial cancer. To validate the
association between polymorphism and endometrial cancer, further studies with
larger numbers of participants worldwide are needed.