TITLE:
Evaluation of the Protection against Infectious Bursal Disease (IBD) Challenge in Progeny Born to Parents Having Received a Vaccination Program Using a Herpesvirus of Turkey-Infectious Bursal Disease (HVT-IBD) Vector Vaccine
AUTHORS:
Stephane Lemiere, Jean-Claude Gauthier, Angeli Kodjo, Laure Vinit, Andrea Delvecchio, Francesco Prandini
KEYWORDS:
Infectious Bursal Disease Virus; Vector Vaccine; ELISA Serology; Protection; Progeny
JOURNAL NAME:
World Journal of Vaccines,
Vol.3 No.2,
May
22,
2013
ABSTRACT: Broiler breeder
vaccination against IBD is usually based on the injection of at least one
inactivated vaccine in oil adjuvant, typically included in a combined vaccine. Priming using one or
several IBD vaccine (s)
has been the most common
way to immunize the breeders so far. In summary, protection against vvIBD
challenge in chicks of one commercial genetic line vaccinated in ovo with the HVT-IBD vector vaccine
was demonstrated. The parents’ IBD vaccination program, using the HVT-IBD vector vaccine
alone, the HVT-IBD vector vaccine plus IBD inactivated vaccine, and inactivated IBD vaccine alone, did not
impair their progeny’s in ovo HVT-IBD
vector vaccine take and subsequent protection against vvIBD virus challenge. An
advantage in terms of immunization of the progeny against vvIBD was shown in
the chicks born to breeders vaccinated with the HVT-IBD vaccine as a primer, as
compared to breeders vaccinated with the inactivated vaccine alone. High level
of IBD maternally-derived antibodies transmitted to the progeny by their parents
induces together with an early onset of immunity by in ovo injection of a HVT-IBD vector vaccine clinical protection,
as monitored on bursas, after vvIBD virus challenge.