TITLE:
Combination Therapy of Multiple Micro Trauma Technology on Hepatocellular Carcinoma
AUTHORS:
Xinfeng Li, Guorong Lu, Dexin Liu, Gaoxiong Wang, Shilin Li, Wei Zhuang
KEYWORDS:
Hepatocellular Carcinoma; Radiofrequency Ablation; Hepatic Artery; Chemoembolization
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.4 No.3,
May
22,
2013
ABSTRACT: Objective: To compare efficacy of therapy scheme as Transhepatic Artery Chemoembolization (TACE) + Radiofrequency Ablation (RFA) + Introportal Vein Chemotherapy (PVC) + Percutaneous Ethanol Injection (PEI) therapy (quadruplet group) with TACE + RFA combinational therapy (diad group) in treating hepatocellular carcinoma (HCC). Methods: 25 cases in quadruplet group were treated by TACE for 3 weeks, then by RFA, after 2 months, by PVC + PEI; 23 cases in diad group were treated by TACE for 3 weeks and then by PEI. After completion of each treatment course in both groups, Alphafetoprotein (AFP) was tested 2 months later; abdomen colorful doppler, CT and AFP were retested 6 months later. Results: AFP was significantly decreased in 23 cases of quadruplet group and 20 cases of diad group among those with AFP positive results. 6 months later, examinations of CT, colorful Doppler and AFP in two groups showed: quadruplet group has significantly decreased (X2 = 6.81, P 0.01) blood supply of cancer tissue and significantly diminished (X2 = 8.29, P 0.01) tumor size, few cases with AFP elevation (X2 = 5.06, P 0.05); lower 1 year relapse rate and two years mortality than that in diad group (X2 = 5.30, P 0.05). Conclusion: TACE + RFA + PVC + PEI combinational therapy is a safe double intervention treatment for HCC scheme with less side effects, which is better than TACE + PEI scheme in killing remnant tumor and reducing relapse.