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M. Gacci, L. Vignozzi, A. Sebastianelli, M. Salvi, C. Giannessi, C. De Nunzio, A. Tubaro, G. Corona, G. Rastrelli, R. Santi, G. Nesi, S. Serni, M. Carini and M. Maggi, “Metabolic Syndrome and Lower Urinary Tract Symptoms: The Role of Inflammation,” Prostate Cancer and Prostatic Diseases, Vol. 16, No. 1, 2013, pp. 101-106. doi:10.1038/pcan.2012.44

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• TITLE: Dietary Modification of Lower Urinary Tract Symptoms with Fermented Whey Product

  AUTHORS: Tiiu Kullisaar, Silver Türk, Margus Punab, Andre Veskioja, Epp Songisepp, Kersti Zilmer, Mihkel Zilmer

  KEYWORDS: Lower Urinary Tract Symptoms (LUTS); Benign Prostatic Hypertrophy (BPH); Prostate; Fermented Whey Product (FWP); Oxidative Stress

  JOURNAL NAME: Open Journal of Urology, Vol.3 No.2, May 17, 2013

  ABSTRACT: After the age of 50, the prostate begins to increase in size. This is known as benign prostatic hypertrophy (BPH). Compression of urethra by enlarged prostate causes dribbling reduced force of the urinary stream, pain and occasional bleeding or infection. This causes difficulty in urinating and requires many men to get up several times during the night to urinate. The aim of our study was to evaluate an influence of new fermented whey based product (FWP) to several biochemical parameters and lower urinary tract symptoms (LUTS). Patients from the outpatient department of Andrology Center were randomized. This study involved the patients with minor to moderate LUTS, International Prostate Symptoms Score (IPSS) range 3 - 19 but not prostatitis (NIH-Chronic Prostatitis Symptom Index (NIH-CPSI) 4 and 2-glass test negative for prostate inflammation and infection). Consumption of the FWP decreased the IPSS score in patients with moderate LUTS/BPH (p 0.001) whereas irritative and obstructive symptoms changed in parallel. There was a correlation between LUTS symptoms change and level of inflammation- and oxidative stress-related indices (blood high-sensitive C-reactive protein, hsCRP; glycated haemoglobin, HbA1c; oxidized low density lipoprotein, oxLDL; interleukine-10, IL-10 and 8-isoprostanes in the urine). Statistically significant changes in mentioned parameters occurred only in study group. Compression of urethra by enlarged prostate explains LUTS in BPH patients. Elevated oxidative stress (OxS) intensifies peroxidation of cell membrane phospholipids. This generates 8-isoprostanes (8-EPI), the prostaglandin-like compounds that can exaggerate LUTS. 8-isoprostanes may cause constriction of bladder and urethra in nanomolar concentrations. Consuming the whey-based product fermented by special lactobacilli strains may improve LUTS as well as OxS and diminish LUTS-related inflammatory response.